Kumar et. al publishes in Kidney International Reports

Dietary Oxalate Induces Urinary Nanocrystals in Humans Nanocrystal Paper Abstract Crystalluria is thought to be associated with kidney stone formation and can occur when urine becomes supersaturated with calcium, oxalate, and phosphate. The principal method used to identify urinary crystals is microscopy, with or without a polarized light source. This method can detect crystals aboveContinue reading “Kumar et. al publishes in Kidney International Reports”

Mitchell et. al publishes review in AJP Renal

Dietary Oxalate and Kidney Stone Formation  Dietary Oxalate and Kidney Stone Formation Review Abstract Dietary oxalate is plant-derived and may be a component of vegetables, nuts, fruits, and grains. In normal individuals, approximately half of urinary oxalate is derived from the diet and half from endogenous synthesis. The amount of oxalate excreted in urine playsContinue reading “Mitchell et. al publishes review in AJP Renal”

Patel et. al publishes in Redox Biology

Oxalate induces mitochondrial dysfunction and disrupts redox homeostasis in a human monocyte derived cell line Oxalate and THP-1 Monocyte Paper Abstract Monocytes/macrophages are thought to be recruited to the renal interstitium during calcium oxalate (CaOx) kidney stone disease for crystal clearance. Mitochondria play an important role in monocyte function during the immune response. We recently determined that monocytes inContinue reading “Patel et. al publishes in Redox Biology”